Employing this drugs with any of the following medicines is just not advised. Your physician may perhaps determine not to deal with you using this type of medication or adjust some of the other medicines you take.
Will not use with another drug that contains acetaminophen without the need of asking your doctor or pharmacist 1st. Acetaminophen is in lots of nonprescription and prescription prescription drugs (for instance ache/fever drugs or cough-and-chilly solutions).
Intestine Blockage. Promethazine/phenylephrine/codeine should not be utilized Should you have a blockage within your gut (bowel obstruction) or even a narrowing with the belly or intestines. Promethazine/phenylephrine/codeine can make these ailments worse.
For those who miss a dose, skip the missed dose and only acquire another dose at your typical time. Never acquire double or additional doses.
Request your medical professional or pharmacist if you should have naloxone accessible to deal with opioid overdose. Teach All your family members or family users with regard to the signs of an opioid overdose and the way to handle it.
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on the codeine drug label cautioning against prescribing codeine to small children of any age to treat agony soon after operation to eliminate tonsils or adenoids. We also issued Drug Safety Communications in July 2015 and September 2015 warning about the potential risk of significant read more respiratory complications in certain kids who metabolized codeine and tramadol considerably faster to their active sort than usual (referred to as ultra-quick metabolism), triggering likely dangerously higher ranges inside their bodies far too swiftly.
Codeine creates a rise in biliary tract force, but lower than morphine or meperidine. Codeine is much less constipating than morphine. Codeine has great antitussive action, Even though a lot less than that of morphine at equivalent doses. It can be Employed in choice to morphine, simply because Unwanted side effects are infrequent at the standard antitussive dose of codeine.
Maternally toxic doses that were about 7 instances the maximum advisable human dose of 360 mg/working day, were being associated with proof of bone resorption and incomplete bone ossification. Codeine didn't exhibit evidence of embrytoxicity or fetotoxicity while in the rabbit model at doses up to 2 moments the most proposed human dose of 360 mg/working day determined by a human body surface area comparison Label. Nonteratogenic consequences
常見之不良反應有：瘙癢、噁心、嘔吐、昏睡、口乾、瞳孔縮小、姿態性低血壓（orthostatic hypotension）、小便不暢、便秘。
These children might be especially sensitive to the respiratory depressant consequences of codeine that's been swiftly metabolized to morphine. Codeine is contraindicated for submit-operative ache management in these patients (see WARNINGS – Dying Associated with Ultra-Immediate Metabolism of Codeine to Morphine and CONTRAINDICATIONS). Excessively significant dosages of antihistamines, together with promethazine hydrochloride, in pediatric clients may possibly result in sudden Dying (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric individuals. In pediatric people that are acutely ill associated with dehydration, there is a heightened susceptibility to dystonias with the use of promethazine HCl.
Browse the Medication Tutorial provided by your pharmacist Before you begin taking acetaminophen/codeine and each time you receive a refill. When you have any issues, inquire your health practitioner or pharmacist.
The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and somewhat soluble in Liquor.
The potency of codeine is unpredictable and it may be hard to tell how it is going to have an effect on Each individual specific mainly because Everybody breaks down codeine in a different way and at distinctive speeds. How speedily codeine has an effect on Additionally you will depend on how you are taking it.